2005 Apr;71(4):338-43. doi: 10.1055/s-2005-864100. 2010;33(3):427-31. doi: 10.1248/bpb.33.427. 1981 Aug;70(8):951-2. doi: 10.1002/jps.2600700833. Based on research in mice, some scientists believe that honokiol may help combat aging by increasing antioxidant enzymes and decreasing levels of methane dicarboxylic aldehyde (13). PMID: 18093712. Cracks and growths on the trunk and branches. Preliminary clinical studies suggest benefits with magnolia for vasomotor symptoms(38), weight management(39), and oral health(40). Shen JL, Man KM, Huang PH, Chen WC, Chen DC, Cheng YW, Liu PL, Chou MC, Chen YH. In the present study, we explored the therapeutic potential of a <i>magnolia</i> extract (BL153 . It does help relax me and it does seem to relieve the kidney pain. n = 5; *P < 0.05 versus LFD group; # Read more: How do you keep magnolias healthy? A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. The https:// ensures that you are connecting to the BL153 prevented obesity-induced renal functional changes. Insulin-induced hexokinase II expression is reduced in obesity and NIDDM. Increased oxidative stress in obesity and its impact on metabolic syndrome. Spoto B, Mattace-Raso F, Sijbrands E, et al. PMID: 18585022. the contents by NLM or the National Institutes of Health. More than 250 ingredients can be found in the bark, flowers and leaves of the Magnolia, but two of the main compounds used in dietary supplements are magnolol and honokiol. Many benefits of magnolia bark can be attributed to two powerful polyphenols magnolol and honokiol. FOIA Experimental data and human studies indicated that 4-HNE, a major oxidation product of membrane lipids, impaired insulin signaling and disrupted the insulin biological activity in skeletal muscle [22]. Take care not to damage any living tissue. 2012 Mar 19;9:57. doi: 10.1186/1742-2094-9-57. It is also used to regulate gastrointestinal motility(50) and is found in herbal formulas such as Ma Zi Ren Wan. In acute myeloid leukemia cells, honokiol inhibited STAT3 signaling via increased protein tyrosine phosphatase SHP1 expression(26). This is a rather serious disease that can lead to the death of the tree if left untreated. Cissus quadrangularis: Uses, Benefits, Side Effects, and Dosage, Galangal Root: Benefits, Uses, and Side Effects. I bought this item because I read a scientific study which said that magnolia bark extract has been able to stop kidney disease from progressing. As a well-known insulin resistance regulator, PGC-1 also has been reported to exert anti-inflammation effects by multiple mechanisms [2729]. government site. Magnolia bark can also be toxic and has been linked to kidney disease and permanent kidney failure. Magnolia bark may alter the effects of drugs that affect the functioning of the cytochrome P450 enzyme. Some of the conditions that magnolia bark has traditionally been used to treat include asthma, anxiety, depression, stomach disorders, and inflammation ( 3, 4 ). ACR was calculated as ACR = urine albumin/urine creatinine (g/mg), as we previously described [36]. During the trial, the treatment group consumed Magnolia along with Phellodendron extract 3 times a day for 6 weeks. Furthermore, our data suggested that the possible mechanism through which BL153 ameliorates renal inflammation and oxidative stress is PGC-1 and HK II upregulation in kidney. Severe canker infections can cause plant death. Over time, this spot becomes increasingly pale until the tissue dies and a brown spot appears. When the weather changes to rainy and stormy conditions are ideal for this disease to develop. Polyphenols, such as those found in magnolia bark, have been suggested as a potential therapy to combat the side effects of oxidative stress and inflammation (12). All of these actions together greatly increase the magnolias chances of recovery. The short-term side effects of magnolia bark are generally mild but can range from headaches, upset stomachs, and dizziness to fatigue, diarrhea, nausea, and dry mouth. PMID: 31240205; PMCID: PMC6556366. Cui W, Li B, Bai Y, et al. Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway. 4-O-methylhonokiol attenuated. It also blocked VEGF-induced Rac to prevent migration of malignant endothelial cells(25), blocked signaling pathways in tumor cells with defective p53(23), and suppressed NF-kB overactivity(24). Introducing the aspect of non-pharmacological treatment of diabetes . The bark of Magnolia officinalis were purchased from Kyungdong market, Seoul, Korea and was taxonomically identified by Dr. Ban Yeon Hwang at the Research Institute of Drug Resource, Chungbuk National University (Cheongju, Korea). The flower and bark of Magnolia have been widely used as traditional herbal remedy for various disorders such as headache, fever, anxiety, diarrhea, stroke, and asthma. 2023 Healthline Media LLC. A similar study in more than 600 menopausal women found that consuming a magnolia bark supplement daily for 12 weeks relieved symptoms of insomnia, irritability, and anxiety (32). Additionally, proteinuria and renal structure changes in HFD-fed mice were much more severe than that in LFD-fed mice. Small studies in humans suggest magnolia may help relieve menopausal symptoms, manage weight, and maintain oral health. Neolignans are a type of polyphenol micronutrient in plants. Epub 2008 Jun 26. Contact dermatitis: In 4 patients following application of magnolia extract-containing cosmetics(44)(45). PMID: 10373217. PMID: 15856410. The ethanol extract of M. officinalis (BL153) was analyzed by HPLC to ensure mainly that it is containing 14.8% of 4-O-methylhonokiol, 14.2% of honokiol, and 12.0% of magnolol, which were in agreement with previously published data [42]. PMID: 28271656; PMCID: PMC5365644. National Library of Medicine Greenberg, M. Journal of Agricultural and Food Chemistry, Nov. 14, 2007; vol 55: pp 9465-9469. Therefore, as long as magnolia bark is used responsibly, there do not appear to be many risks associated with its use. As blood moves through the body, it picks up extra fluid, chemicals and waste. PMID: 16454147. Avoid using magnolia during pregnancy. Data were collected from five animals for each group and presented as means SD. If the infestation is on the branch, cut it off below the affected area. Xu H, Barnes GT, Yang Q, et al. Kidney weight was normalized by tibia length (a). These findings might lead to the development of brands of gum that contain this ingredient. The magnolia extract improved health issues such as anxiety, insomnia, depression, and libido. Wu R, Wyatt E, Chawla K, et al. A 24-week study in 89 menopausal women experiencing symptoms of sleep and mood alterations were given a supplement containing 60 mg of magnolia bark extract and 50 mg of magnesium daily. Moreover, the organic components such as magnolol and honokiol found in the extract have strong antioxidant properties, which may help fight free radicals off the skin. PMID: 22429472; PMCID: PMC3325890. Kalman DS, Feldman S, Feldman R, Schwartz HI, Krieger DR, Garrison R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. found that honokiol administration obviously reduced airway hyperresponsiveness in ovalbumin-induced allergic asthma mice, accompanied by proinflammatory cytokines significantly reduction [15]. During the six-month feeding, body weight was measured every month, and the gavage volume was justified based on the body weight change. Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora) on cortisol and psychological mood state in moderately stressed subjects. However, all these structure alterations were alleviated after six months of BL153 treatment at a dose of 5mg/kg or 10mg/kg (Figure 2). Suma Root: Nutrients, Benefits, Downsides, and More, Sorrel: Nutrients, Benefits, Downsides, and Recipes, 15 Impressive Herbs with Antiviral Activity, Anti-Inflammatory Diet 101: How to Reduce Inflammation Naturally, 13 of the Most Anti-Inflammatory Foods You Can Eat, The Signs and Symptoms of Too Much Stress. Some early case studies of women undergoing weight management treatment reported kidney issues caused due to a preparation containing magnolia bark, however, further analysis revealed possible contamination, adulteration, or use of substandard products as the cause of kidney damage. Zhang GS, Wang RJ, Zhang HN, Zhang GP, Luo MS, Luo JD. Today, magnolia bark extract is readily available in pill form. Statistical significance was considered as P < 0.05. Spray the leaves and petioles with an aqueous solution of copper fungicide. Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JM. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. Does Magnolia Bark affect Thyroid function? However, the mechanism underlying the generation of insulin resistance in obesity has not been fully understood. Typically, magnolia bark is bark of the houpo magnolia tree that has been stripped away from it branches and stems to make supplements. In current study, we provide the first evidence that magnolia extract, BL153, attenuates obesity-associated renal structural and functional changes in an HFD-induced obesity mouse model. Is magnolia poisonous to humans? Allergies. In addition, ameliorating inflammation and oxidative stress by using MG132 or sulforaphane showed beneficial effects in diabetic nephropathy [36, 37]. Taken together, it is possible that magnolia extract (BL153) attenuates kidney inflammation and oxidative stress via increasing PGC-1-mediated various antioxidative protein expressions under different conditions. Xu et al. Spray the leaves and petioles with an aqueous solution of copper fungicide. The pathogens get into cracks in the bark or where the trunk and branch come together. They are not round, but angular or irregular in shape. The mixture also increased serotonin metabolite levels in the frontal cortex, striatum, and nucleus accumbens at 40 mg/kg. Another study in 180 menopausal women determined that a supplement containing magnolia bark, soy isoflavones, and lactobacilli more effectively reduced the severity and frequency of hot flashes than a supplement containing the soy isoflavones alone (33). PMID: 17949053. Mailloux RJ, Dumouchel T, Aguer C, Dekemp R, Beanlands R, Harper M-E. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Phytomedicine. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. J Agric Food Chem. In traditional medicine, Magnoliae officinalis cortex mainly acts to dry dampness and disperse phlegm, lower Qi, and eliminate fullness. Epub 2016 Oct 6. If the disease has affected the branch, cut it off a little closer to the trunk. In murine models, honokiol enhanced low-dose docetaxel treatment against prostate cancer growth and bone metastasis(37), and reduced breast tumor growth biomarkers(48). Researchers also noticed that magnolia extract could have a strong anti-inflammatory effect. They also discovered that cortisol levels in the treatment group remained low in the evening and at bedtime. EDRF-release and Ca+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb. Usually in spring, when the weather is warm and humid, the pathogens settle on young leaves and begin to germinate. 2012 Nov;63(6):1191-9. doi: 10.1016/j.neuropharm.2012.06.031. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Use it several times at 1-2 week intervals. Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. Can Magnolia Bark extract be used for Acne? Last medically reviewed on April 7, 2020, Cissus quadrangularis is a plant that has long been used as a natural remedy to treat a wide variety of ailments. Careers, Unable to load your collection due to an error. No adverse effects related to magnolia bark or the compounds it contains have been observed. A voucher specimen was deposited at the Herbarium of Chungbuk National University, Chungbuk, Korea. PMID: 23924268; PMCID: PMC3750820. Obesity is considered as a state of chronic low-grade systemic inflammation and oxidative stress, which interact with each other and cause a vicious circle, promoting the development of insulin resistance [19, 20]. PMID: 20877235; PMCID: PMC6257695. Spray the leaves, petioles, and branches with an aqueous solution of copper fungicide. The disease results in large growths on the tree that are much larger than the branch or trunk on which they are growing. Irregular heartbeat. Similarly, increased kidney 3-NT and 4-HNE expression caused by HFD feeding were all prevented by BL153 treatment (Figure 4). As shown in Figure 6, HK II protein expression was decreased in kidney of HFD group mice compared with LFD group mice; however, it was almost back to normal level by BL153 administration at indicated doses (Figure 6). The soy isoflavones were more effective for hot flashes, vaginal dryness, nocturnal sweating, and palpitations [R, R]. Honokiol: A Review of Its Anticancer Potential and Mechanisms. Digestive problems. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. As mentioned, magnolia bark extract appears to have protective effects against many neurological conditions. Today we will look at the most common magnolia diseases and how to treat them. Planta Med. Magnolia Bark has been used for over 1,000 years in traditional Chinese Medicine without indications of safety concerns. Some studies have prescribed concentrated magnolia bark extracts for up to 1 year without any observations of adverse effects (1). To examine overall morphology, paraffin sections were dewaxed for H&E staining. Magnolol suppresses metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in PC-3 human prostate carcinoma cells. Nevertheless, magnolia bark appears to be a safe therapy that may help treat menopause symptoms. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Nutr J. Magnolia bark can also be toxic and has been linked to kidney disease and permanent kidney failure. A second study in mice observed similar outcomes after administering honokiol, which also decreased the amount of time it took the mice to fall asleep and transition into non-REM sleep (28). A mixture of honokiol and magnolol at 20 and 40 mg/kg inhibited stress-induced decreases of serotonin in the frontal cortex, hippocampus, striatum, hypothalamus, and nucleus accumbens in mice. Huang HC, Hsieh WY, Niu YL, Chang TM. ", Natural Medicines Professional Database: "Magnolia. Only then can it exhibit its maximum antimicrobial potential. Anti-oxidant: protects against free radicals and decelerates the aging process. Corticosterone and serotonin each play a role in regulating anxiety, mood, and depression. However, optimal doses of magnolia have not been set for any condition. 2008 Apr 1;32(3):715-25. doi: 10.1016/j.pnpbp.2007.11.020. 2018 Nov;84(16):1151-1164. doi: 10.1055/a-0642-1966. ScienceDaily, 20 November 2007. PMID: 18426577; PMCID: PMC2359758. Epub 2018 Jun 20. The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy. The next study was to explore the possible mechanism by which BL153 attenuates kidney inflammation and oxidative stress in obesity. As a potential P-glycoprotein inhibitor, constituents of magnolia bark extract may reduce multidrug resistance in cancer cells via P-gp downregulation(42)(43). Not enough is known to rate the safety of topical supplements with Magnolia Bark applied to the skin. Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community. Munroe ME, Businga TR, Kline JN, Bishop GA. Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma. Thus, it cannot be said with certainty that the effects were due solely to the magnolia bark. PMID: 31877856; PMCID: PMC7016989. Therefore, compounds such as BL153, with therapeutic efficacy and distinct mechanisms from MG132 and sulforaphane, have great potential for treatment of obesity-associated nephropathy. Magnolol causes alterations in the cell cycle in androgen insensitive human prostate cancer cells in vitro by affecting expression of key cell cycle regulatory proteins. To evaluate renal function, urinary albumin and urinary creatinine were detected, and based on which, urinary albumin-to-creatinine ratio (ACR) was calculated. Magnolia bark is a powerful supplement prepared from the bark, leaves, and flowers of the houpo magnolia tree. Urinary albumin and creatinine levels were examined to reflect renal function. Molecules. This article reviews galangal root's benefits and safety, as well as how it, Elecampane root is a folk medicine that may have several health benefits. Always disinfect tools when pruning. The .gov means its official. Protein bands were visualized using enhanced chemiluminescence (Thermo scientific, Rockford, IL). Antitumor activity also occurred via MMP9 inhibition through the NF-kB pathway in breast cancer cells(19) and through AMPK activation in colorectal cancer cells(18). Kidney weight to tibia length ratio (Figure 2(a)) and kidney hematoxylin and eosin (H&E) staining were undertaken to evaluate the protective effects of BL153 on obesity-induced kidney structure changes. If wood decay progresses, use the services of a tree treatment company. Symptoms are bark deformation in the place where the disease is developing. The beneficial effects of magnolol on learning and memory abilities were reported to be associated with superoxide dismutase (SOD) restoration in a scopolamine-induced mouse model [26]. In lab tests using rats fed a high-fat diet, magnolol and honokiol reduced fat and protected against insulin resistance. A combination of honokiol and magnolol normalized biochemical abnormalities in brain 5-HT and 5-HIAA, serum corticosterone levels, and platelet adenylyl cyclase activity, a biomarker for depression in chronically stressed rodents(7). Chiang J, Shen Y-C, Wang Y-H, et al. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. J Pharm Sci. PMID: 27721050. What you eat can have a big effect on inflammation in your body. Lab studies of magnolia bark extract suggest anti-inflammatory and anticancer properties, but studies in humans are needed. Zhang J, Chen Z, Huang X, Shi W, Zhang R, Chen M, Huang H, Wu L. Insights on the Multifunctional Activities of Magnolol. Planta Med. Effects of magnolol on impairment of learning and memory abilities induced by scopolamine in mice. As shown in Figure 2, kidney weight to tibia length ratio was increased in HFD-fed mice compared with low fat diet- (LFD-) fed mice. One of the representative medicinal plants is the Magnolia genus, which is mainly distributed in East and Southeast Asia. Shortness of breath. Magnolia bark may cause kidney failure after long-term use. Sedative and anti-anxiety agents: The constituents of, Anti-coagulants: Magnolia interferes with. In glioma cells, it induced autophagy and activated a p53/cyclin D1/CDK6/CDK4/E2F1-dependent pathway to induce apoptosis and cell cycle arrest(34) and in prostate cancer cells, honokiol suppressed c-Myc protein expression(30). Lo YC, Teng CM, Chen CF, Chen CC, Hong CY. Additional studies and research is required to establish a relationship between thyroid function and magnolia bark usage if any. I want to help other fitness enthusiasts in their journey to a healthier lifestyle and avoid wasting their time on ineffective supplements the same way I did in the past. Once cool, place the vessel overnight in a refrigerator allowing further extraction of petals. Honokiol Inhibits Constitutive and Inducible STAT3 Signaling via PU.1-Induced SHP1 Expression in Acute Myeloid Leukemia Cells. As the worldwide prevalence of obesity is increasing, more attention has been given to obesity-related complications, including kidney disease. Avoid keeping the ground around the magnolia constantly moist. And the quality and active ingredients in supplements may vary widely from maker to maker. This makes it hard to set a standard dose. Its vasorelaxant action and antioxidant properties may contribute to reducing elevated blood pressure. Comparisons between groups were performed by one-way ANOVA, followed by Tukey's post hoc test. Urine albumin (Bethyl Laboratories, Montgomery, TX) and urinary creatinine (BioAssay Systems, Hayward, CA) were measured according to the manufacturers' instructions. The houpo magnolia tree is native to China, where it has been used for thousands of years as a supplement in traditional Chinese medicine. The knockdown of PGC-1 by specific small interfering RNA greatly reduced mitochondrial antioxidative protein expression [29]. P < 0.05 versus HFD group. The results showed that inflammation markers (tumor necrosis factor- and plasminogen activator inhibitor-1) and oxidative stress markers (3-nitrotyrosine and 4-hydroxy-2-nonenal) were all significantly increased in the kidney of HFD-fed mice compared to mice fed with a low fat diet (LFD). Jiang S, Zhang L-F, Zhang H-W, et al. Remove the gall with a sharp, sterile knife. PMID: 29925102. Diabetes. Biofactors. After the studies, researchers found that the treatment group did not gain any weight as opposed to the placebo group. Currently, there are no official recommendations for magnolia bark dosage. The leaves and flowers from the tree are sometimes used as well. It usually affects older trees. Magnolia bark appears to have many potential benefits, including anticancer properties, improved sleep, treatment of menopause symptoms, relief of stress and anxiety, and protection against oxidation and inflammation. Magnolia bark can have interactions with the following classes of drugs: Magnolia bark can cause addiction given its sedative effects. It has also been used as a sleeping aid. Does Magnolia Bark have any interactions with other supplements? As a result, light gray spots appear on the leaf blade about half an inch across. People who use benzodiazepine may use magnolia bark as a natural sedative. In addition, we also investigated the protective effects of BL153 on obesity-induced oxidative stress by examining 3-nitrotyrosine (3-NT, Figure 4(a)) as an index of nitrosative damage and 4-hydroxy-2-nonenal (4-HNE, Figure 4(b)) as an index of oxidative damage in the next study. This study was supported, in part, by Chungbuk Technopark Grant Bio-International Collaborating Research, funded by Chungbuk Province, Republic of Korea, and a collaborative project between University of Louisville and Bioland Co. Ltd. for Screening Antidiabetes and/or Obesity Naturally Extracted Compounds, funded by Bioland Co., Ltd. (10-0826 Bioland). Two antiplatelet agents from Magnolia officinalis. Diabetes treatment is a complicated process in which, in addition to the standard pharmacological action, it is necessary to append a comprehensive approach. Vazquez-Carballo A, Ceperuelo-Mallafre V, Chacon MR, et al. One way in which honokiol may combat cancer is by helping regulate cell signaling pathways. This suggests that it has potential as a therapeutic agent for neurodegenerative diseases like Alzheimers. Click the links below to access the individual topic pages: This article makes use of information from the U.S. National Library of Medicine under the terms of the Creative Commons Attribution 4.0 International License. In our present study, a novel finding was that PGC-1 was increased by more than 10-folds after BL153 treatment. and transmitted securely. However, long-term use is not recommended due to a lack of safety data. Kidney-shaped tray, kidney dish kidney/Renal failure - medical magnolia bark, white willow bark, white kidney bean - medical non cancerous mass in a kidney with a lesion in the middle - medical Only kidney present loss of tissue - medical pass a kidney stone more. Research on honokiol has found that it can reduce inflammation in the brain and spinal cord specifically, partly due to its ability to cross the blood-brain barrier (14). After a while, a hole may appear in the center of the spot. American Chemical Society. If the gall grows around the trunk, the sap flow can be interrupted and the tree will die. The disease is most active during the warm summer months. Here is a closer look at some of the potential benefits of magnolia bark. Drug users may misuse magnolia bark for its feel-good effect. 2013 Aug 7;10(1):37. doi: 10.1186/1550-2783-10-37. For example, 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis, prevents the development and progression of Alzheimer's disease by improving oxidative stress through a p38 MAPK-dependent pathway [25]. Biomed Res Int. A literature review reveals that the following group of people can misuse it: The review suggests that its easy availability, affordability, potent effects, favorable legal status, and natural origin may contribute to its misuse and addiction. Effect of a sugar-free chewing gum containing magnolia bark extract on different variables related to caries and gingivitis: a randomized controlled intervention trial. 6 Benefits and Side Effects of Relora (Sleep, Weight Loss), 4 Benefits of Phellodendron Bark Extract (for Dopamine, Skin? After a while, fluid begins to ooze out of the area where the disease is. The bark, leaves, and flowers of the houpo magnolia tree are used in traditional medicine to treat anxiety, depression, and more. Some of the conditions that magnolia bark has traditionally been used to treat include asthma, anxiety, depression, stomach disorders, and inflammation (3, 4). In human bladder cancer cells, it induced p27KIP1-mediated G2/M-phase cell cycle arrest to activate the extracellular signal-regulated kinase pathway(11), and decreased binding of transcription factor NF-kB to DNA to inhibit MMP9 expression(12). Weisinger JR, Kempson RL, Eldridge FL, Swenson RS. The International Obesity Task Force has determined that the global numbers of adults and school-aged children considered obese in 2010 were 600 million and 50 million, respectively. Mean glomerular area was also measured to evaluate the glomerular enlargement. The extract of the bark of Magnolia trees (Magnolia officianalis) has been used for some 1,000 years in traditional Chinese and Japanese medicine for treatment of maladies ranging from asthma to depression to headaches to muscle pain. The bark possesses calming, antimicrobial, anti-inflammatory, and antioxidant effects. Agosta C, Atlante M, Benvenuti C. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause. Other interactions: Taking magnolia bark with blood thinners, including aspirin, is not recommended. Biphenyl-type neolignans from, Shih HC, Hwang TL, Chen HC, et al. Honokiol, a multifunctional antiangiogenic and antitumor agent. Though the use of magnolia bark is common in traditional Chinese medicine, you may wonder what current research says about the tree bark. It is generally considered safe if taken orally and for the short term. In THP-1 cells, magnolol and honokiol reduced inflammatory TNF- and IL-8 production induced by Propionibacterium acnes (3). 2016 Sep 24;17(10):1629. doi: 10.3390/ijms17101629. Additionally, a test-tube study found that magnolol inhibited the growth of lung cancer cells (21, 22). See additional information. Data in humans are limited. Additionally, the magnolol appeared to increase the number of times the mice woke up during sleep but decrease the length of time they were awake. P < 0.05 versus HFD group. Stroke. Rajgopal A, Missler SR, Scholten JD. Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. Magnolol affects expression of IGF-1 and associated binding proteins in human prostate cancer cells in vitro. Furukawa S, Fujita T, Shimabukuro M, et al. Algal leaf spot is a disease that affects trees and shrubs with thin, leathery leaves. Furthermore, an animal study concluded that chronic treatment with magnolia bark extract has an antihypertensive effect. When there's a problem with the kidneys, whether it's kidney disease or kidney stones, avoiding or limiting certain foods in your diet may help improve kidne. As a result, their appearance is severely damaged, although it is rarely fatal to the tree. n = 5; *P < 0.05 versus LFD group; # The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress. Magnolia bark extract has been tested in studies as an ingredient in chewing gum. Throw away any damaged leaves far away from the yard. However, young trees can be severely damaged if the disease is noticed too late.